Endocrine Abstracts

Background: Immuglobulin 4 (IgG4) is the least common subtype of Immoglobulin G. However due to its unique characteristic it has been the focal point of many research projects, which eventualy led to the discovery of the sytemic fibro-inflammatory disorder called IgG4-Related Disease. The potential role of IgG4 in the pathogenesis of autoimmune thyroid diseases has been also suggested. However, the amount of evidence is still limited, especially in Graves Disease (GD).<p c...

Background: Graves disease with elevated Immunoglobulin G4 serum concentration is a novel subtype of Graves disease (GD), which seems to be particularly associated with Graves orbitopathy (GO). It occurs in 17.6% of patients with GO and 5.4% of patients with GD without GO. In this study, we compare multiple magnetic resonance imaging (MRI) features of GO with elevated IgG4 serum concentration (IgG4-GO) with the classic GO subtype without IgG4 elevation. No such research has be...

Background: The impact of subclinical hyperthyroidism (sHT) on lipids concentration is still unclear. The aim of the study was to prospectively evaluate the changes in lipid profile in patients with sHT and following restoration of euthyroid state.Patients and methods: The studied group consisted of 44 patients (37 females, 7 males), diagnosed with endogenous sHT in the course of either toxic multinodular goiter, diffused thyroid autonomy or autonomously...